- Oxford Brain Imaging Genetics Server - BIG40. This open data server contains results from GWAS of almost 4,000 imaging-derived phenotypes from the multimodal brain imaging in UK Biobank, using data from the 40,000 subject imaging data release from early 2020. The discovery sample size was 22,138 and the replication sample was 11,086. Chromosomes 1:22 and X are included, resulting in association tests with 20,381,044 genetic variants.
The work was funded by the Wellcome Trust. Compute resources were provided by the Oxford Biomedical Research Computing (BMRC) facility (a joint development between Oxford's Wellcome Centre for Human Genetics and the Big Data Institute, supported by Health Data Research UK and the NIHR Oxford Biomedical Research Centre). This work was conducted in part using the UK Biobank Resource under Application Number 8107.
Lloyd T. Elliott and Winfield Chen (Department of Statistics and Actuarial Science, SFU), Stephen M. Smith, Gwenaëlle Douaud, Fidel Alfaro-Almagro, Paul McCarthy, Duncan Mortimer (Wellcome Centre for Integrative Neuroimaging), Sinan Shi (Department of Statistics, University of Oxford) and Kevin Sharp (Genomics PLC) contributed to the creation and distribution of these data.